#MACVECTOR DISPLAY AS DOUBLE STRANDED CODE#

The align to reference algorithm has been slightly tweaked to do a better job of aligning reads that have insertions relative to the reference. Improved Align to Reference SNP Reporting

The main application icon and window toolbar appearance have been updated to match the macOS Big Sur “look and feel”. Other than the ability to run natively on M1 processors, MacVector 18.1.1 is essentially identical to MacVector 18.0.1 with the exception that the embedded Python framework has been updated to version 3.9. MacVector 18.1 is a Universal Binary, meaning that it can run natively on both Intel and Apple Silicon Macintosh computers. MacVector 18.1 is a Universal Binary application that means it runs natively on Apple Silicon and Intel Macs. To reduce clutter in the Assembly Project window toolbar, all of the assembly algorithms have been consolidated into a single Assemble toolbar button with a dropdown menu. This functionality replaces the old Primer Converter utility. You can import primer data into a MacVector Primer Database (.nsub) file from an Excel or CSV formatted file. Importing of Primer Databases in TSV or CSV Format Where a window has a context-sensitive menus available these views now contain a “hamburger” button (three parallel horizontal lines) that displays the same context sensitive menu when clicked on. There is a new Remove Gaps context-sensitive (right-click) menu option that deletes residues in reads that correspond to a gap in the consensus sequence. When aligning ABI chromatogram data, or plain sequences, the Map tab now graphically displays the “trimmed” regions at either end of the sequences. In addition, the Sensitivity setting can now be lower due to the enhanced consecutive gap detection, which also speeds up calculations. The alignment algorithm has been further optimized for speed. The Align to Reference alignment algorithm has been overhauled to do a much better job handling larger numbers of gaps in the alignment between a reference sequence and a read. It is supported on macOS Sierra (10.12) to macOS Monterey (12).

MacVector 18.2 is a Universal Binary that runs natively on both Apple Silicon and Intel Macs.

As usual there’s been a lot of bug fixes and changes that you probably do not care about! But be assured that everything we do makes MacVector a future proof and modern macOS application that you can rely on!.

Importing Sequencher project (.SPF) files has been significantly enhanced.

Long sequencing reads from PacBio and ONT sequencers can now be assembled in Align to Reference.

You can also basecall heterozygotes in a trace file in the Single Trace Editor. The tool works on multiple trace files in the Assembly project manager or the Align to Reference editor.

#MACVECTOR DISPLAY AS DOUBLE STRANDED CODE#

You can also analyze Sanger trace files and permanently change the basecalled sequence with an IUPAC ambiguity code representing the called heterozygote. The heterozygote analysis tool analyzes one or multiple Sanger trace files and reports on all possible heterozygotes. Heterozygote Analysis of Sanger trace files It is supported on macOS High Sierra to macOS Ventura and is a Universal Binary that will run natively on Apple Silicon Macs as well as existing Intel Macs. MacVector 18.5 was developed and tested on macOS Ventura. ( See here for a detailed history of releases) MacVector 18.5 Overview

Macvector display as double stranded